スゴイねぇ！GEN-003 (*^^)v 症状とウィルスの排出を ↓

日曜だというのに、仕事に追われている銭型でございます… (-"-)

今日は、またもや仕事の合間に「ボーッ」とネットで探し物をしていたのですが、そうしたら！

　　「GEN-003 が Phase 1で、症状だけでなく、ウィルスの排出も抑制した」

という記事を見つけました！!(^^)!

色んなワクチン研究で、「発症期間が短くなった」、「症状が軽くなった」などの報告は良くあるのですが…、

　ウィルスの排出が51％少なくなった（つまり、49%＝半分以下）

というものは少ないように思います !(^^)!

記事の最後の方にも書いてあるのですが、まだ、Phase 1ですので、これから効果検証を目的とした Phase 2、より多くの人に対する安全性検証を目的とした Phase 3 を乗り越えていくには、まだまだ時間が必要です…。

ただ、このGEN-003にしろ、HSV529にしろ、新しいアプローチでのワクチン開発がどんどん進んでいるように思います。

今後の動きに、注目ですね ☆


http://www.admitonevip.com/herpes-cure-2014-new-discoveries-to-battle-the-infection/

Genocea Herpes Vaccine: GEN-003
Genocea Biosciences is one of the many institutions trying to develop a new way to deal with herpes. Although this prospect treatment is still not completed, results have been positive so far. Say hello to herpes cure 2014, the GEN-003.
The leading candidate to battle genital herpes is GEN-003. This new vaccine is designed to lessen the duration and the intensity of the symptoms of the disease. Not only that, it also aims to regulate the transmission of the virus. It also aims to reduce viral shedding which is how the virus gets easily contracted. This protein subunit vaccine is expected to respond well with the immune system.
The vaccine is known to contain antigens that are have demonstrated resistance against the disease and reduced the duration of the symptoms and viral shedding. Clinical trials are now being made to see if the vaccine will work. In the Phase 1 clinical trial conducted by Genocea, there are 143 participants. All participants had HSV-2.

How Does It Work
The vaccine works by working on the T cells. It activates these cells so that they can better handle the outbreaks of the virus. The vaccine will enable the T cells to quickly identify and take down the infection before it can actually reach the surface of the skin. Because of that, the immune system is quicker when dealing with the virus.

How is the Vaccine Given
GEN-003 is administered to the participants by injections, 3 injections in series to be particular. Booster shots are also given at certain times to make sure that the vaccine is active. The vaccine may not take out the virus but it definitely is a good alternative than taking anti-viral drugs every now and then.

Results
The first clinical trial for the vaccine has been successful. GEN-003 shows promising results for the treatment of herpes. There was a significant reduction seen in the viral shedding by 51%. With this reduction, the chance of transmitting herpes to sexual partners would lessen.
With the success of the Phase 1 clinical trial, GEN-003 will enter the Phase 2 hoping that it bears positive results. The first phase is normally conducted to volunteers. It aims to determine the side effects and other factors.
Since Phase 1 was a success, Phase 2 begins which will focus most especially on the efficiency of the vaccine. The participants will be compared to another set of participants taking another treatment. This phase normally lasts for 2 years.
The third phase follows with an estimated duration of 3 years. This will tackle more on the safety of the vaccine. Various populations will be studied to cater other factors. Different dosages will be tested too.
The arrival of this herpes cure 2014, the GEN-003, gives much hope to those who suffer from the disease. The path to reaching the goal is still far but as long as there is perseverance, one can always triumph.